Calcium folinate

 
Chemical Formula: C₂₀H₂₁CaN₇O₇

Molecular Weight: 511.5

CAS Number: 1492-18-8

Description: Calcium folinate USP, White to light yellow powder, >98.0% (HPLC)

Calcium folinate (CF) is a calcium salt of the calcium formyl tetrahydrofolate derivative, being the activated form of folic acid in the body. Calcium folinate is an antidote of the folic acid antagonists (such as methotrexate, pyrimethamine or trimethoprim, etc.). It can be used for the treatment of megaloblastic anemia. In combination with fluorouracil, it is used for the treatment of advanced colon cancer and rectal cancer.